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Recent advances in soft electronics have attracted great attention due in large to its potential applications in personalized bio-integrated healthcare devices. The mechanical mismatch between conventional electronic/optoelectronic devices and soft human tissues/organs, however, often causes various challenges, such as the low signal to noise ratio of biosensors, inflammations and/or excessive immune responses near implanted sites, and discomfort and consequent stress to users by these devices. Ultra-flexible and stretchable electronic devices have low system modulus and intrinsic softness and solve these issues. Here, our unique strategies in the synthesis of nanoscale materials, their seamless integration with electronics, and unconventional device designs toward wearable and implantable integrated biomedical systems are presented. Another device example includes minimally invasive surgical tools to solve specific cardiovascular and colorectal diseases. These implantable, minimally invasive, and wearable bioelectronic systems combine recent breakthroughs in unconventional soft electronics to address unsolved issues in the clinical medicine.
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